Table 1. MicroRNAs associated functional pathways in SK/exo.
| # | KEGG pathway | # of genes | # of microRNAs | P-value |
|---|---|---|---|---|
| 1 | Glycosaminoglycan biosynthesis (hsa00532) | 154 | 31 | <1e-16 |
| 2 | TGF-beta signaling pathway (hsa04350) | 78 | 29 | 4.33E-06 |
| 3 | Focal adhesion (hsa04510) | 124 | 25 | 3.96E-05 |
| 4 | Wnt signaling pathway (hsa04310) | 76 | 21 | 2.47E-04 |
| 5 | Ubiquitin mediated proteolysis (hsa04120) | 47 | 17 | 2.10E-04 |
| 6 | Non-small cell lung cancer (hsa05223) | 52 | 23 | 1.38E-04 |
The exosomes secreted from SK-LU-1 cells were collected and miRNA profiling was performed. Using microT-CDs target-predicting data set along with mirPATH software, we characterized the top KEGG pathways predicted for interaction enrichments for miRNAs in SK/exo. Ln(P-value) is a natural logarithmic scale of the P-value obtained from a χ2 test comparing expected number of genes with interaction and the actual number composing the pathways (DIANA algorithm).