Table 4.
Association between ABCB1 C3435T genotypes and clinico-pathological characteristics of breast cancer in Moroccan patients
| Variable | Total | C3435T polymorphism genotypes | P value | ||
|---|---|---|---|---|---|
| CC (%) | CT (%) | TT (%) | |||
| Histology | 60 | ||||
| IDC | 54 | 26 (48.1) | 19 (35.2) | 9 (16.7) | 0.44 |
| ILC | 3 | 1 (33.3) | 1 (33.3) | 1 (33.3) | |
| Others | 3 | 3 (100.0) | - | - | |
| Tumor size | 60 | ||||
| T1 | 7 | 2 (28.6) | 3 (42.9) | 2 (28.6) | 0.41 |
| T2 | 29 | 15 (51.7) | 8 (27.6) | 6 (20.7) | |
| T3 | 11 | 8 (72.7) | 3 (27.3) | - | |
| T4 | 13 | 5 (38.5) | 6 (46.2) | 2 (15.4) | |
| SBR | 60 | ||||
| I | 3 | 2 (66.7) | - | 1 (33.3) | 0.61 |
| II | 45 | 23 (51.1) | 16 (35.6) | 6 (13.3) | |
| III | 12 | 5 (41.7) | 4 (33.3) | 3 (25.0) | |
| Node involvement | 60 | ||||
| N- | 25 | 13 (52.0) | 7 (28.0) | 5 (20.0) | 0.78 |
| N+ | 34 | 17 (50.0) | 12 (35.2) | 5 (14.7) | |
| Progesterone receptors status | 60 | ||||
| PR- | 27 | 16 (59.3) | 8 (29.6) | 3 (11.1) | 0.38 |
| PR+ | 33 | 14 (42.4) | 12 (36.4) | 7 (21.2) | |
| Estrogen receptors status | 60 | ||||
| ER- | 22 | 14 (63.6) | 5 (22.7) | 3 (13.6) | 0.27 |
| ER+ | 38 | 16 (42.1) | 15 (39.5) | 7 (18.4) | |
CC homozygous wild-type, CT heterozygous, TT homozygous mutant, % percentage, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, SBR Scarff–Bloom–Richardson, ER estrogen receptor, PR progesterone receptor