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. 2016 Aug 31;13(1):224. doi: 10.1186/s12974-016-0672-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Microglial phagocytic activity is enhanced by chronic social defeat. a Representative examples of phagocytosis of neuronal debris are shown. Microglia from homecage (HC) and acute (ASD) or chronic social defeat (CSD) were incubated for 3 h with fluorescently labeled ultraviolet-irradiated neural cells and stained with anti-CD11b. Confirmation of phagocytosis is provided in orthogonal projections of confocal z-stacks shown in the HC picture. Scale bar = 20 μm. b Bar graphs compare surface area of ultraviolet-irradiated neural cells (NC) to total surface area (mean ± s.e.m.) of HC, ASD, and CSD microglia (**P < 0.001; one-way ANOVA; representative experiment shown out of three independently performed)