Table 1.

Synthetic library of β-nitrostyrenes.

Compound	Basic moiety	R	R'	R“	Yieldsa (%)	M.P.(°C)	M.P.reference
1		4-Cl	H	H	81	112–114	113–114
2		4-Cl	H	Me	82	88–90	89–91
3		4-Cl	H	Et	80	105–107
4		4-NMe2	H	H	91	186–188	186–188
5		4-NMe2	H	Me	96	90–91
6		4-NMe2	H	Et	92	77–79
7		4-NO2	H	H	90	94–96	94–96
8		4-NO2	H	Me	89	114–116	114–115
9		4-NO2	H	Et	81	104–106	103.5–104.5
10		3-NO2	H	H	79	124–126	125
11		3-NO2	H	Me	81	80–82
12		3-NO2	H	Et	84	84–86
13		4-OMe	H	H	89	86–88	85–87
14		4-OMe	H	Me	88	44–46	44–45
15		4-OMe	H	Et	73	Oil	Oil
16		4-OH	H	H	76	168–169	167–171b
17		4-OH	H	Me	72	122–124	124–125
18		4-OH	H	Et	71	60–62
19		3-OH	H	H	79	138–140	136–140b
20		3-OH	H	Me	81	96–98	96–98
21		3-OH	H	Et	79	82–84
22		3,4-dimethoxy	H	H	88	140–142	142–144
23		3,4-dimethoxy	H	Me	89	70–72	71–72
24		3,4-dimethoxy	H	Et	91	78–80	78–79
25		4-OH	Me	H	77	88–90
26		3-OH	Me	Et	74	138–140
27		2-OH,3-OEt	H	H	87	128–130
28		-	H	H	89	134–136
29		-	H	Me	91	182–184
30		-	H	Et	86	64–66

^aIsolated yields.

^bbMelting points of compounds from sigma aldrich.