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. 2016 Aug 8;157(9):3604–3620. doi: 10.1210/en.2016-1191

Figure 8.

Figure 8.

E2, but not the ERβ-selective agonist DPN, modulates M-current, mEPSC, and sEPSC in PVN CRH neurons from ERα KO females. A, I-V plot of M-current from −75 to −30 mV under control and E2 (10 min, 100nM) conditions in ERα KO females (n = 5, P < .05 at −40, −35, and −30 mV). E2 perfusion rapidly potentiates (B) the amplitude but not (C) the frequency of mEPSC and (D) the amplitude but not (E) the frequency of sEPSC in ERα KO females (n = 4 each). DPN (10 min, 100nM) perfusion in ERα KO females had no significant effect on (F) the M-current, mEPSC (G) amplitude or (H) frequency, or sEPSC (I) amplitude or (J) frequency (n = 4 each). All I-V plots were analyzed with a repeated-measures, two-way ANOVA and post hoc Newman-Keuls comparisons. EPSC data were analyzed by a paired Student's t test (*, P < .05). NS, no significant difference (P > .05).