Figure 1.

Loss of 11β-HSD1 does not protect mice from the adverse metabolic effects from being fed the ALIOS diet for 16 weeks. A, Body weight. B, Adipose depot weights; 11β-HSD1KO mice showed statistically significant differences only in mesenteric depot weights. C, Muscle bed weights. D, Glucose tolerance. E, Insulin tolerance. F, Fed and fasted blood glucose concentrations. G, Plasma insulin concentrations at T0 and T30 after glucose bolus injection. H, Total, HDL, and LDL plasma cholesterol concentrations. I, Plasma FFA. J, Plasma TAG. SCF, sc fat; GF, gonadal fat; MF, mesenteric fat; PRF, perirenal fat; TA, tibialis anterior. Mean ± SEM; **, P < .01 using Student's t test; n = 13 (controls) and n = 11 (11β-HSD1KO).