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Increased expression of fibrosis-associated gene does not correlate with histological phenotype. A, Significant increases in Col1a1 mRNA, a marker of fibrosis, in 11β-HSD1KO mice. Hepatic stellate cell marker Reelin (Reln), was not increased. B, Assessment of fibrosis using trichrome stained sections cut at 5 μm showed no ectopic collagen in either control or 11β-HSD1KO mice. Mean ± SEM; **, P < .01 using Student's t test; n = 13 (control) and n = 11 (11β-HSD1KO). Scale bars, 100 μm.
