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. 2016 Aug 1;9(8):863–871. doi: 10.1242/dmm.024307

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — QTL analyses identify genetic regions contributing to high IOP in YBR mice. (A) A genome-wide scan using IOP values as a quantitative trait in N2 mapping progeny identified two significant QTLs: on chromosome 4 and chromosome 17. The blue, green and red lines indicate the significance thresholds at 1%, 5% and 10%, respectively. Both the chromosome 4 and chromosome 17 regions show LOD scores above the 1% threshold. (B) A genome-wide scan of only black mice (Tyrp1^Y/B, with no iris disease) identified a significant QTL on chromosome 17.