Fig. 7.

IgLON5 IgG1, but not IgG4 antibodies, cause a reduction of surface IgLON5 clusters. a Hippocampal neurons were treated for 3 days with IgG1 or IgG4 fractions from control serum or from a patient with IgLON5 antibodies and immunostained for surface antibody-bound IgLON5. Scale bar = 5 μm. b Quantification of IgLON5 clusters. IgLON5 clusters were significantly reduced after treatment with patient IgG1 compared with control IgG1 or patient and control IgG4. *p < 0.05