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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Cancer Discov. 2016 Apr 5;6(6):594–600. doi: 10.1158/2159-8290.CD-15-1192

Figure 1.

Figure 1

Comparison of histologic features between primary rectal neuroendocrine tumor and liver metastasis. Histologic examination show a submucosal mass consisting of nested/organoid proliferation of variably small cells with stippled chromatin with some cells exhibiting pink granular cytoplasm (A-B). Immunohistochemical stains are diffusely positive for synaptophysin (C) and chromogranin (not shown), with variable CDX2 staining (D). Panels E-H highlight similar features from the liver biopsy with uniform cells (E-F), scattered mitotic figures (arrows), diffuse synaptophysin positivity (G) and Ki67 proliferative index 40–50% (H).