Table 2.
Summary of HRCT Findings
| Select HRCT Feature | All (n=200) | IPF (n=134) | Non-IPF (n=66) | P# |
|---|---|---|---|---|
|
| ||||
| Reticular density* | 0.83 (0.50–1.25) | 1.00 (0.58–1.33) | 0.63 (0.17–1.00) | 0.0001 |
| No (%) | 184 (92.0) | 128 (95.5) | 56 (84.9) | 0.009 |
| Ground glass* | 0.17 (0.00–0.83) | 0.17 (0.00–0.67) | 0.50 (0.00–1.25) | 0.02 |
| No (%) | 121 (60.5) | 77 (57.5) | 44 (66.7) | 0.21 |
| Bronchiectasis* | 0.17 (0.00–0.33) | 0.17 (0.00–0.33) | 0.17 (0.00–0.25) | 0.01 |
| No (%) | 135 (67.5) | 97 (72.4) | 38 (57.6) | 0.04 |
| Mosaic attenuation* | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.27 |
| No (%) | 26 (13.0) | 15 (11.2) | 11 (16.7) | 0.28 |
| Septal thickening* | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.49 |
| No (%) | 40 (20.0) | 29 (21.6) | 11 (16.7) | 0.41 |
| Micronodules* | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.03 |
| No (%) | 9 (4.5) | 6 (9.1) | 3 (2.2) | 0.06 |
| Axial distribution, No. (%) | ||||
| Peripheral/subpleural | 164 (82.0) | 114 (85.1) | 50 (75.8) | 0.11 |
| Central | 0 | 0 | 0 | – |
| Evenly distributed | 33 (16.5) | 19 (14.2) | 14 (21.2) | 0.21 |
| None | 3 (1.5) | 1 (0.8) | 2 (3.0) | 0.25 |
| Craniocaudal distribution, No. (%) | ||||
| Upper predominant | 6 (3.0) | 4 (3.0) | 2 (3.0) | 1.00 |
| Lower predominant | 122 (61.0) | 77 (57.5) | 45 (68.2) | 0.14 |
| Diffuse | 69 (34.5) | 52 (38.8) | 17 (25.8) | 0.07 |
| None | 3 (1.5) | 1 (0.8) | 2 (3.0) | 0.25 |
*
Shown is the median (IQR) of the HRCT composite for the referenced HRCT finding, on a scale of 0–4, with the range for the entire cohort. No. (%) cited indicates the number of subjects in each group with whole-lung composite > 0.
#
P generated via Wilcoxon Rank Sum test (continuous variables) or Fisher’s Exact test (categorical variables), comparing IPF to Non-IPF groups.