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. 2016 Aug 18;9:24–31. doi: 10.1016/j.dib.2016.07.062

Fig. 5.

Fig. 5

Illustration of the ILK signaling pathway generated using QIAGEN׳s Ingenuity® Pathway Analysis, differentially regulated under GAG interaction conditions. The proteins in red and green indicate higher and lower abundance levels under GAG interaction conditions, respectively. In addition, the figure also illustrates that TNF-α participates in the upstream regulation of this pathway. The arrows indicate predicted regulation, activation (→) or inhibition (⊢). The proteins used in this analysis were filtered using the following criteria: minimum of 2.0-fold change and quantitation ANOVA, p-value ≤ 0.05. ECM protein-extracellular protein; FAK - Focal adhesion kinase; PI3K − 1 Phosphatidyl inositol 3 kinase; ILKAP - Integrin-linked kinase-associated serine/threonine phosphatase 2C; ILK - Integrin-linked protein kinase; PARVβ- Parvin beta; RICTOR - Rapamycin-insensitive companion of mTOR; PXN – Paxilin; VCL – Vinculin; Filamin-binding LIM protein 1; KIND2 - Fermitin family homolog 2; TESK1 - Dual specificity testis-specific protein kinase 2; PARVα - Parvin alpha; PDK1 − 3-phosphoinositide-dependent protein kinase 1; AKT - Protein Kinase B; CASP3 - Caspase-3; PIP3 - Phosphatidylinositol (3,4,5)-trisphosphate; PIP2 - phosphatidylinositol biphosphate; PI3K − 1 Phosphatidyl inositol 3 kinase; PTEN - Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; IRS - Insulin receptor substrate; PINCH - LIM and senescent cell antigen-like-containing domain protein; TB4 - Thymosin beta-4; RSU1 - Ras suppressor protein 1; RTK - Receptor tyrosine kinase; PP2A - Protein phosphatase 2A; NCK2 - Cytoplasmic protein NCK2; DOCK 180 - Dedicator of cytokinesis protein 180; TNFR - tumor necrosis factor receptor; GSK3 - Glycogen synthase kinase-3; JNK - c-Jun N-terminal Protein Kinase; mTOR - Serine/threonine-protein kinase mTOR; NACA - Nascent polypeptide-associated complex subunit alpha; ERK 1/2 - Mitogen-activated protein kinase ERK 1/2; CTNNβ - Catenin (Cadherin-Associated Protein), Beta; MSK 1/2 - Mitogen and stress activated protein kinase 1/2; CREB - Cyclic AMP-responsive element-binding protein; LEF 1- Lymphoid enhancer-binding factor 1; cJUN – Jun Proto-Oncogene; cFOS – FBJ Murine Osteosarcoma viral oncogene homolog; HIF 1α - Hypoxia-inducible factor 1-alpha; c-MYC - Myc proto-oncogene protein; iNOS - Nitric oxide synthase, inducible; COX2 - Prostaglandin G/H synthase 2; MMP9 - Matrix metalloproteinase-9; VEGF - Vascular endothelial growth factor; SLUG - Zinc finger protein SNAI2; FN1 – Fibronectin; RHO - Ras-like GTP-binding protein Rho; DSP – Desmoplakin; KRT 18 - Keratin, type I cytoskeletal 18; MUC – Mucin; VIM – Vimentin. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article).