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Conformational changes detected by site-specific antibodies to α-synuclein. Multiple site-specific antibodies (displayed above peptides corresponding to residues 1–10, 11–20, 21–30, 31–40, 41–50, 51–60, 61–70, 75–91, 104–119, and 131–140 of α-synuclein) (upper panel) were used for dot blot analysis of α-synuclein monomer and fibrils (lower panel). Marked differences in immunoreactivity between the monomer and fibrils can be seen.
