Figure 3.

Conversion of normal α-synuclein protein to the abnormal form in cultured cells by transduction of amyloid-like protein seeds. (A) Seeded aggregation of α-synuclein in SH-SY5Y cells overexpressing α-synuclein upon transfection with preformed α-synuclein fibrils. Abundant phosphorylated α-synuclein aggregates are formed, which resemble Lewy bodies in the brain, both morphologically and biochemically. (B) Schematic illustration of molecular events associated with the formation of intracellular amyloid-like proteins.