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Structural and biochemical differences between normal and abnormal α-synuclein in the human brain
| State | Structure | Solubility | Reactions to antibodies | ||
|---|---|---|---|---|---|
| PS129 | Anti-Ub | Anti-p62 | |||
| Healthy (normal) | Unstructured, long-range interactions, ThioS (−) | Buffer-soluble | P129 (−) | Ub (−) | p62 (−) |
| Disease (abnormal) | Filamentous/fibrous, cross-β, ThioS (+) | Sarkosyl-insoluble | P129 (+) | Ub (+) | p62 (+) |
