Figure 8.

Structures of selected epigenetic drugs. Three nucleoside analogs are known that can inhibit DNA methylation after incorporation into DNA. 5-aza-CR (Vidaza) and 5-aza-CdR (decitabine) have been FDA approved for the treatment of the preleukemic disorder, myelodysplasia. Two HDAC inhibitors are also FDA approved for cutaneous T-cell lymphoma and several others are in clinical trials. Drugs targeting other epigenetic processes are in earlier stages of clinical development (see also Figs. 5 and 6 of Audia and Campbell 2014).