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Drugs that target viral motors with high stoichiometry. (A) Homotetrameric AM2-BM2 channel protein of influenza virus complexed with the inhibitory drug molecule rimantadine (PDB accession number 2RLF) (117); (B) illustration of allosteric HIV-1 integrase inhibitors that act by promoting high-order oligomerization of integrase to block its activity; (C) bedaquiline that targets ATP synthase (PDB accession number 4V1H).
