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Progression of symptoms in mice inoculated via the i.c. route with 104 FFU (A) or via the i.m. route with 106 FFU (B) of CE(NiP) or CE(NiP)ΔP2-5. The mice infected via the i.c. route and those infected via the i.m. route were observed daily for 14 and 24 days, respectively. The symptoms in mice were classified into 5 grades: (i) normal, (ii) body weight loss, (iii) mild neurological symptoms, (iv) severe neurological symptoms, and (v) death.
