Evolutionary fingerprints of restriction factors and other well-characterized genes. (A) Evolutionary fingerprinting analysis detected three clusters: canonical arms race genes (red), positively selected genes (green), and SERINC/other genes (blue/black). Notably, the SERINC genes do not cluster with the canonical arms race genes. (B) Average evolutionary fingerprints for the SERINC genes (blue) and the canonical arms race genes (red), confirming that the canonical arms race genes have strong support for sites with high nonsynonymous (β)-to-synonymous (α) rate ratios, whereas the SERINC genes do not.