FIG 7.

Conservation of ASCT2-binding domains in the SU subunit of Dasy-Env1.1 and other retroviral Env proteins. Shown is a sequence alignment of SU protein subunits, from the methionine to the putative furin cleavage site. Virus names are indicated on the left, along with their host range. Variable regions are indicated, along with the number of omitted residues; dashes correspond to deletions. The conserved motif shown to be essential for the syncytin-1/hASCT2 interaction (SDGGGX2DX2R) is highlighted in red, and the three cysteine-containing motifs (PCXC, CYX5C, and CX7-9CW) and the amino acids that are highly conserved among retroviral members of the type D interference group are highlighted in yellow (see reference 48). DrERV, coding sequence reconstituted from the DrERV_216 noncoding Env sequence (GenBank accession number KP175581).