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. 2016 Aug 26;90(18):8105–8114. doi: 10.1128/JVI.00883-16

TABLE 1.

Average virus titers in organs of infected mice

Virus Avg virus titer (mean log10 TCID50/ml ± SD)a
1 dpi
3 dpi
5 dpi
Nasal turbinate Lung Nasal turbinate Lung Nasal turbinate Lung
Wild type 2.08 ± 0.29 3.08 ± 0.58 4.12 ± 0.38 5.83 ± 0.38 3.42 ± 0.14 5.58 ± 0.14
PA-K356R 2.33 ± 0.14 3.33 ± 0.14 4.67 ± 0.14 6.25 ± 0.43 4.25 ± 0.66* 6.42 ± 0.58*
PB2-E627K 2.42 ± 0.14 3.50 ± 0.25 4.83 ± 0.38 6.75 ± 0* 4.75 ± 0.66* 6.42 ± 0.58*
PA-K356R/PB2-E627K 2.67 ± 0.14 3.83 ± 0.38 5.83 ± 0.14*# 6.83 ± 0.38* 5.08 ± 0.29* 6.50 ± 0.25*
a

Lower limits of detection were 101.25 TCID50/ml for nasal turbinates or lungs. * indicates that the virus titer of the corresponding mutant strain was significantly higher than that of the wild-type virus, and # indicates that the virus titer of the corresponding mutant strain was significantly higher than that of the PB2-E627K virus, with a P value of <0.05, as determined by one-way ANOVA.