FIG 7.

PEDV inhibits the type I interferon pathway. Vero E6 and IPEC-J2 cells were either mock infected or infected with PEDV at an MOI of 0.1 for 36 h; they were then treated with IFN-α (10 U/ml) or IFN-γ (10 U/ml) for different times as indicated. Vero E6 (A) and IPEC-J2 (B) cells were collected and lysed and were then subjected to Western blot analysis with an anti-STAT1 antibody or an anti-phospho-STAT1 (Tyr701) antibody. Densitometric data for p-STAT1/actin ratios from three independent experiments are expressed as means ± SD. *, P < 0.05. The P value was calculated using Student's t test.