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Effects of PF-46393 analogues on WT pNL4-3 HIV-1 replication kinetics in Jurkat T cells. Jurkat T cells were transfected with WT pNL4-3 and cultured with 5 μM compound or an equivalent volume of DMSO. Cells were split at regular intervals, and supernatants were reserved at each time point for RT analysis. The dashed line represents the peak day (day 12) of WT NL4-3 replication when cultured in DMSO.
