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Effect of PF-46393 analogues on pNL4-3 CA mutant replication in Jurkat T cells. Jurkat T cells were transfected with pNL4-3/WT or SP1-A3V, CA-G156E, CA-157S, CA-P160L, or CA-G225D derivatives and cultured with either 5 μM compound or an equivalent volume of DMSO. Cells were split at regular intervals, and supernatants were reserved at each time point for RT analysis. The dashed line represents the peak day (day 10) of WT NL4-3 replication when cultured in DMSO.
