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. 2016 Mar 16;5:16011. doi: 10.1038/mtm.2016.11

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Histopathological grading of ocular inflammation in New Zealand White rabbits intravitreally injected with four doses (2E9, 2E10, 2E11, and 1.5E12 vg/eye) of AAV8-scRS/IRBPhRS and vehicle. Findings from the injected eye are displayed for each animal at four time points (2 weeks, 3, 6, and 9 months postinjection). The severity of the inflammatory reaction in different eye compartments was graded according to the number of inflammatory cells and classified as follows, minimal <100 inflammatory cells, mild 100–250 inflammatory cells, moderate 250–500 inflammatory cells and severe >500 inflammatory cells. Each symbol in the figure represents a single animal.