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. 2016 Mar 16;5:16011. doi: 10.1038/mtm.2016.11

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Biodistribution of AAV8-scRS/IRBPhRS in the vitreous humor and blood of New Zealand White rabbits injected with four doses (2E9, 2E10, 2E11, and 1.5E12 vg/eye) of AAV8-scRS/IRBPhRS and vehicle. The mean ± SD copy numbers of AAV8-scRS/IRBPhRS DNA in the vitreous humor of the injected eye (a) and blood (b) of New Zealand White rabbits are shown at five time points (pretreatment, 2 weeks, 3, 6 and 9 months after injection) for all vector doses and vehicle. Pretreatment vector DNA copy numbers in the rabbit vitreous were not assayed and the values marked by an asterisk correspond to the number of vector genomes which were injected into the vitreous. Copy numbers of AAV8-scRS/IRBPhRS are reported as copies/20 µl vitreous humor or copies/100 ng blood.