Table 1.
SNP | Chr | Positiona | Gene | Alleleb | EAFc | OR (95% CI)d | P d | P FDR e | Effectsf | P hete g | I 2 |
---|---|---|---|---|---|---|---|---|---|---|---|
rs3115672 | 6 | 31727897 | MSH5 | C/T | 0.106 | 1.20 (1.14–1.27) | 3.99E-11 | 3.30E-08 | + + + + + + | 0.266 | 22.30 |
rs114596632 | 6 | 30879987 | GTF2H4 | C/T | 0.114 | 1.19 (1.12–1.25) | 5.40E-10 | 2.23E-07 | + + + + + + | 0.462 | 0.00 |
rs3748522 | 12 | 1058688 | RAD52 | C/A | 0.481 | 0.92 (0.89–0.95) | 2.11E-06 | 5.81E-04 | − − − − + + | 0.108 | 44.61 |
rs11571475 | 12 | 1022352 | RAD52 | A/G | 0.134 | 0.90 (0.85–0.95) | 3.32E-05 | 6.86E-03 | − − − − + − | 0.641 | 0.00 |
rs1056503 | 5 | 82648977 | XRCC4 | T/G | 0.120 | 1.11 (1.06–1.18) | 6.23E-05 | 8.02E-03 | + + + + + + | 0.515 | 0.00 |
rs506120 | 15 | 43802024 | TP53BP1 | C/T | 0.279 | 0.92 (0.89–0.96) | 6.53E-05 | 8.02E-03 | − − − − + − | 0.420 | 0.00 |
rs11571376 | 12 | 1059556 | RAD52 | C/G | 0.290 | 0.92 (0.89–0.96) | 6.96E-05 | 8.02E-03 | − + − − − − | 0.113 | 43.82 |
rs12563994 | 1 | 155244092 | CLK2 | C/T | 0.243 | 1.09 (1.04–1.13) | 7.77E-05 | 8.02E-03 | + − + + − + | 0.200 | 31.39 |
rs7334543 | 13 | 32973276 | BRCA2 | A/G | 0.256 | 0.93 (0.89–0.96) | 1.49E-04 | 1.37E-02 | − − − − + − | 0.208 | 30.32 |
rs707937 | 6 | 31731014 | MSH5 | C/G | 0.180 | 0.91 (0.87–0.96) | 2.30E-04 | 1.90E-02 | − − + − − − | 0.234 | 26.79 |
rs2035990 | 5 | 82649467 | XRCC4 | T/C | 0.069 | 1.13 (1.06–1.21) | 3.63E-04 | 2.73E-02 | + + + + + + | 0.106 | 44.97 |
rs28628574 | 15 | 43802038 | TP53BP1 | A/C | 0.103 | 0.90 (0.85–0.95) | 4.05E-04 | 2.79E-02 | − − + − − − | 0.960 | 0.00 |
rs9534160 | 13 | 32888021 | BRCA2 | G/A | 0.049 | 1.15 (1.06–1.25) | 7.65E-04 | 4.56E-02 | + + + + + − | 0.433 | 0.00 |
rs4246215 | 11 | 61564299 | FEN1 | G/T | 0.358 | 0.94 (0.91–0.97) | 7.73E-04 | 4.56E-02 | − − − − − + | 0.120 | 42.76 |
SNP, single nucleotide polymorphisms; FDR, false discovery rate; Chr, chromosome.
aBased on NCBI build 37 of the human genome.
bReference allele/effect allele.
cEffect allele frequency.
dMeta-analysis additive model P-value based on six lung cancer GWASs.
eFalse discovery rate (FDR) correction.
fEffects by study: ICR, MDACC, IARC, NCI, SLRI and GLC, respectively. + represents OR > 1.00, and − represents OR < 1.00.
g P value for heterogeneity.