Table 3.
Association of two SNPs in GTF2H4 and MSH5 with DNA repair capacity (DRC) among 869 controls with mRNA expression levels of corresponding gene in 270 lymphoblastoid cell lines from HapMap
| rs114596632 in GTF2H4 | P a | P adj b | rs3115672 in MSH5 | P a | P adj b | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Phenotype | CC | CT | TT | CC | CT | TT | ||||
| DRC | ||||||||||
| N (%) | 676 (77.8) | 181 (20.8) | 12 (1.4) | 688 (79.2) | 172 (19.8) | 9 (1.0) | ||||
| Mean ± SD | 9.16±3.33 | 8.67±2.85 | 7.80±2.30 | 0.027 | 0.032 | 9.07±3.28 | 8.97±3.09 | 7.40±1.88 | 0.34 | 0.277 |
| mRNA expression | ||||||||||
| N (%) | 230 (87.1) | 33 (12.5) | 1 (0.4) | 102 (38.9) | 116 (44.3) | 44 (16.8) | ||||
| Mean ± SD | 8.12±0.24 | 8.01±0.22 | 7.98 | 0.017 | 0.031 | 6.96±0.17 | 6.92±0.19 | 6.92±0.22 | 0.148 | 0.417 |
a P value was estimated from a generalized linear model.
bAdjustment for age, sex, and pack-years of smoking in the DRC correlation analysis; adjustment for populations (CEU, YRI, Asian) in the expression correlation analysis.