Table 3.
rs114596632 in GTF2H4 | P a | P adj b | rs3115672 in MSH5 | P a | P adj b | |||||
---|---|---|---|---|---|---|---|---|---|---|
Phenotype | CC | CT | TT | CC | CT | TT | ||||
DRC | ||||||||||
N (%) | 676 (77.8) | 181 (20.8) | 12 (1.4) | 688 (79.2) | 172 (19.8) | 9 (1.0) | ||||
Mean ± SD | 9.16±3.33 | 8.67±2.85 | 7.80±2.30 | 0.027 | 0.032 | 9.07±3.28 | 8.97±3.09 | 7.40±1.88 | 0.34 | 0.277 |
mRNA expression | ||||||||||
N (%) | 230 (87.1) | 33 (12.5) | 1 (0.4) | 102 (38.9) | 116 (44.3) | 44 (16.8) | ||||
Mean ± SD | 8.12±0.24 | 8.01±0.22 | 7.98 | 0.017 | 0.031 | 6.96±0.17 | 6.92±0.19 | 6.92±0.22 | 0.148 | 0.417 |
a P value was estimated from a generalized linear model.
bAdjustment for age, sex, and pack-years of smoking in the DRC correlation analysis; adjustment for populations (CEU, YRI, Asian) in the expression correlation analysis.