Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Mar 23;3:16002. doi: 10.1038/mto.2016.2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

PMC Copyright notice

Characteristics of the double deleted oncolytic vaccinia virus expressing DAI. (a) Schematic figures of the virus constructs. Two novel armed vaccinia viruses were generated expressing human (vvdd-tdTomato-hDAI) or murine DAI (vvdd-tdTomato-mDAI). Both viruses express also tdTomato fluorescent protein as a reporter gene and are deleted in thymidine kinase and vaccinia growth factor genes. (b) DAI-expression does not hinder virus replication and cell killing efficacy. MTS cell viability assays were performed in several cell lines 5 days postinfection. Virus expressing human DAI was used for human cell lines and mDAI-virus for the mouse cell line B16-OVA.