Skip to main content
. 2016 Apr 20;3:16011. doi: 10.1038/mto.2016.11

Figure 1.

Figure 1

Toxicities of chimeric antigen receptor (CAR) T-cell therapy. Depiction of reported/potential toxicities following the use of CAR T cells: insertional oncogenesis (theoretical); neurological toxicity; “on-target, off-tumor” toxicity (engagement of target antigen on nonpathogenic tissues); anaphylaxis/allergy (host reaction to foreign antigen expressed by the CAR T cell); cytokine release syndrome (systemic inflammatory response following activation of CAR T cells). CRP, C-reactive protein.