Table 1. Patient characteristics at ICU admission.
| IFI n = 78 | No IFI n = 659 | P value | |
|---|---|---|---|
| Age | 58 (48–64) | 61 (50–70) | 0.08 |
| Male gender | 46 (59.0%) | 397 (60.2%) | 0.83 |
| Underlying malignancy | 209 (31.7%) | 0.37 | |
| Non-Hodgkin lymphoma | 23 (29.5%) | 180 (27.3%) | |
| Acute myeloid leukemia | 20 (25.6%) | 90 (13.7%) | |
| Myeloma | 7 (9.0%) | 40 (6.1%) | |
| Acute lymphocytic leukemia | 9 (11.5%) | 57 (8.6%) | |
| Chronic lymphocytic leukemia | 5 (6.4%) | 13 (2.0%) | |
| Chronic myeloid leukemia | 2 (2.6%) | 20 (3.0%) | |
| Myelodysplastic syndrome | 1 (1.3%) | 14 (2.1%) | |
| Hodgkin lymphoma | 3 (3.8%) | 36 (5.5%) | |
| Other malignancies | 8 (10.3%) | ||
| Newly diagnosed malignancy ¥ | 22 (28.2%) | 261 (39.6%) | 0.06 |
| Partial or complete remission | 19 (24.4%) | 155 (23.5%) | 0.88 |
| BMT / HSCT | 0.02 | ||
| No | 49 (62.8%) | 504 (76.5%) | |
| Autologous | 11 (14.1%) | 70 (10.6%) | |
| Allogeneic | 18 (23.1%) | 85 (12.9%) | |
| Chemotherapy in the last 7 days | 72 (92.3%) | 519 (78.8%) | 0.004 |
| Neutropenia | 34 (43.6%) | 174 (26.4%) | 0.002 |
| Reasons for ICU admission £ | |||
| Acute respiratory failure | 69 (88.5%) | 329 (49.9%) | < 0.0001 |
| Shock | 52 (66.7%) | 308 (46.7%) | 0.001 |
| Acute renal failure | 9 (11.5%) | 146 (22.2%) | 0.03 |
| Sepsis | 78 (100%) | 398 (60.4%) | < 0.0001 |
| Systemic antifungal agents | 59 (76%) | 224 (34%) | < 0.0001 |
| Life-sustaining therapies | |||
| Mechanical ventilation (invasive or noninvasive) | 65 (83.3%) | 374 (56.8%) | 0.02 |
| Vasopressors | 52 (66.7%) | 308 (46.7%) | 0.001 |
| Renal replacement therapy | 22 (28.6%) | 167 (26.0%) | 0.73 |
| Outcomes | |||
| Length of ICU stay | 9 (5–17) | 5 (3–10) | < 0.0001 |
| ICU mortality | 32 (41.0%) | 158 (24.0%) | 0.002 |
| Length of hospital stay | 9 (5–17) | 5 (3–10) | < 0.0001 |
| Hospital mortality | 42 (53.8%) | 231 (35.1%) | 0.002 |
| BG concentrations (pg/mL) were higher in patients with than without IFI (144 (77–510) vs. 50 (30–125), < 0.0001) | 144 (77–510) | 50 (30–125) | < 0.0001 |
¥
Hematological malignancy diagnosed in the past 2 weeks.
£
Some patients were admitted for more than one reason.
IFI, invasive fungal infection; BMT, bone marrow transplant; HSCT, hematopoietic stem-cell transplant; ICU, intensive care unit; BG, (1–3)-β-D-glucan.