Table 1. EC50a (μM) derived from TO displacement (FID) by selected AQ and AN derivatives from G4 folded KIT sequences.
AQ1 | AQ5 | AQ3 | AQ7 | AN6 | |
---|---|---|---|---|---|
KIT1 | 0.32 ± 0.05 | 0.27 ± 0.02 | 0.50 ± 0.04 | 0.24 ± 0.04 | 4.11 ± 0.70 |
KIT2 | 0.35 ± 0.05 | 0.41 ± 0.03 | 0.62 ± 0.05 | 0.25 ± 0.02 | 3.63 ± 1.00 |
ligand concentration that displaces 50% of TO from tested DNA sequences.