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. 2016 Mar 8;7(16):21775–21785. doi: 10.18632/oncotarget.7982

Figure 1. DSGOST inhibition of VEGF-induced angiogenic abilities in vitro.

Figure 1

(A) The effect of DSGOST on the viability in HUVECs was determined by the MTT assay (mean ± SD; n = 6). *P = 0.004 versus untreated cells. (B) Cell migration. DSGOST at the indicated concentrations inhibits VEGF-induced migration in cell scratching assays (left). †P = 0.004 versus untreated cells and *P = 0.0001, 0.0003, 0.0001 versus only VEGF-treated cells. Representative images of cell migration results (right). (C) Cell invasion. DSGOST at the indicated concentrations inhibited VEGF-induced cell invasiveness in two-chamber assays (left). †P = 0.0003 versus untreated cells and *P = 0.0002, 0.0003, 0.0001 versus only VEGF-treated cells. Representative images of cell invasion results (right). (D) Tube formation. DSGOST inhibits VEGF-induced tube formation (left). †P = 0.0004 versus untreated cells and *P = 0.296, 0.0002, 0.0003 versus only VEGF-treated cells. The representative images of tube formation results (right).