Figure 7. A proposed model of PRL-3-mediated suppression in lung cancer.

The schematic showed that PRL-3 inhibited cell invasion and migration through suppressing Slug expression via the reduced AKT phosphorylation and GSK3β signaling. PRL-3 overexpression would decrease AKT phosphorylation at Ser⁴⁷³, and in turn, the dephosphorylated AKT reduces the phosphorylation of GSK3β and enhances GSK3β activity, leading to the down-regulation of β-catenin and Slug, and the up-regulation of E-cadherin. Enhanced PRL-3 expression also inhibited SRC and ERK phosphorylation, which may lead to the inhibition of lung cancer cell proliferation.