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. 2016 Mar 9;7(16):21952–21967. doi: 10.18632/oncotarget.8009

Figure 6. Levels of MMP-9, CREBBP, and EP300 are increased in head and neck squamous cell carcinoma samples.

Figure 6

(A) The expression of MMP-9 among 12 cancer types from The Cancer Genome Atlas (TCGA) Data Portal from Broad GDAC Firehose data portal. The mRNA RPKM (Reads per Kilobase of exon model per Million) reads per million mappable reads of all samples were selected and analyzed for comparing abundances by the website of Broad GDAC Firehose. (B) The expression of MMP-9 in normal and head and neck squamous cell carcinoma from TCGA Data Portal. ***p < 0.05. (C) Relative expression of MMP-9, CREBBP, and EP300 in 45 pairs of head and neck squamous cell carcinoma tumor tissues and their corresponding adjacent non-cancerous tissues. (D) The correlations among mRNA levels of CREBBP and EP300 as well as MMP-9 in head and neck squamous cell carcinoma. A significant correlation was found between CREBBP and EP300 (Spearman rank correlation coefficient r = 0.64, p < 0.001) as well as MMP-9 (r = 0.46, p < 0.001). (E) A model depicting reciprocal regulation between melatonin and MMP-9 transcription in oral cancer. UCEC: uterine corpus endometrial carcinoma. STES: stomach and esophageal carcinoma. STAD: stomach adenocarcinoma. LUSC: lung squamous cell carcinoma. LUAD: lung adenocarcinoma. LIHC: liver hepatocellular carcinoma. KIRC: kidney renal clear cell carcinoma. KIPAN: pan-kidney cohort. HNSC: head and neck squamous cell carcinoma. ESCA: esophageal carcinoma. BRCA: breast invasive carcinoma. BLCA: bladder cancer.