Table 1. Association data for the most significant SNPs in the case-control study of all CUP patients shown in Figure 1.
SNP | Chr | Position | Risk allele* | MAFctrl | OR_het | OR_hom | P_Geno | OR_Allele | P_Allele | P** | I2** | Gene | Location | Distance |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs9347983 | 6 | 165386880 | G | 0.24 | 1.45 | 1.85 | 1.1×10−5 | 1.40 | 1.4×10−6 | 0.46 | 0.0 | RP11-300M24.1 | flanking 3′UTR | 224kb |
rs741828 | 7 | 155616377 | T | 0.25 | 1.46 | 2.06 | 7.2×10−7 | 1.44 | 1.1×10−7 | 0.19 | 40.0 | Y RNA | flanking 3′UTR | 55Kb |
rs2660852 | 12 | 94969679 | C | 0.36 | 1.33 | 2.50 | 7.4×10−7 | 1.44 | 1.9×10−7 | 0.81 | 0.0 | LTA4H | flanking 5′UTR | 8.2kb |
rs4771282 | 13 | 97144122 | T | 0.39 | 1.56 | 1.94 | 7.4×10−7 | 1.40 | 1.4×10−7 | 0.35 | 3.9 | RP11-12OE13.1 | flanking 5′UTR | 16Kb |
rs477145 | 21 | 31684281 | T | 0.31 | 1.47 | 1.93 | 1.2×10−6 | 1.42 | 1.1×10−7 | 0.05 | 66.9 | TIAM1 | intron | −50673 |
rs2835931 | 21 | 38043518 | T | 0.24 | 1.53 | 1.89 | 1.8×10−6 | 1.43 | 4.0×10−7 | 0.51 | 0.0 | KCNJ6 | intron | −34214 |
The risk is calculated to the risk allele
Heterogeneity for data from the 3 centers