Table 4. Stratified analyses of rs2292832 polymorphism on cancer risk.

Comparisons	Heterogeneity test			Summary OR (95% CI)	Hypothesis test		Studies
	Q	P	I2 (%)		Z	P
Ethnic Asian
C vs T	51.04	< 0.01	49	0.90 (0.81,1.01)	1.86	0.06	16
CT vs TT	18.78	0.22	20	0.94 (0.88,1.01)	1.70	0.09	16
CC vs TT	33.84	0.01	41	0.93 (0.78,1.11)	0.79	0.43	16
CT + CC vs TT	3.93	0.02	44	0.94 (0.87,1.03)	1.31	0.19	16
CC vs CT + TT	32.41	0.02	38	1.00 (0.88,1.14)	0.08	0.94	16
Caucasian
C vs T	2.55	0.28	22	1.06 (0.84,1.33)	0.47	0.63	4
CT vs TT	4.73	0.19	37	1.02 (0.82,1.25)	0.14	0.89	4
CC vs TT	10.45	0.02	61	1.16 (0.67,2.01)	0.54	0.59	4
CT + CC vs TT	6.09	0.11	11	1.08 (0.88,1.31)	0.72	0.47	4
CC vs CT + TT	8.12	0.09	51	1.10 (0.86,1.41)	0.79	0.43	5
Cancer types
Colorectal Cancer
C vs T	0.79	0.67	0	0.97 (0.85,1.10)	0.48	0.63	3
CT vs TT	0.02	0.99	0	0.85 (0.71,1.02)	1.72	0.09	3
CC vs TT	1.02	0.60	0	0.94 (0.71,1.25)	0.42	0.68	3
CT + CC vs TT	1.12	0.57	0	0.87 (0.67,1.15)	0.97	0.33	3
CC vs CT + TT	0.32	0.96	0	1.13 (0.97,1.33)	1.56	0.12	3
Lung Cancer
C vs T	3.65	0.16	45	0.97 (0.86,1.08)	0.63	0.53	3
CT vs TT	1.99	0.37	0	0.86 (0.67,1.11)	1.14	0.25	3
CC vs TT	4.43	0.11	55	0.93 (0.73,1.20)	0.53	0.60	3
CT + CC vs TT	1.62	0.44	0	1.03 (0.83,1.28)	0.25	0.80	3
CC vs CT + TT	3.28	0.19	39	0.96 (0.83,1.12)	0.48	0.63	3
Breast Cancer
C vs T	13.72	< 0.01	55	0.82 (0.61,1.10)	1.31	0.19	3
CT vs TT	2.19	0.33	9	0.86 (0.72,1.03)	1.64	0.10	3
CC vs TT	5.81	0.55	46	0.82 (0.65,1.03)	1.73	0.08	3
CT + CC vs TT	2.72	0.26	26	0.83 (0.70,0.98)	2.18	0.03	3
CC vs CT + TT	2.82	0.24	29	0.80 (0.68,0.93)	2.81	0.00	3
Other cancers
C vs T	13.42	0.06	45	0.91 (0.78,1.05)	1.29	0.20	11
CT vs TT	19.35	0.04	48	0.96 (0.85,1.08)	0.75	0.45	11
CC vs TT	16.28	0.02	57	1.06 (0.83,1.35)	0.47	0.64	11
CT + CC vs TT	13.67	0.09	41	1.06 (0.96,1.16)	1.17	0.24	11
CC vs CT + TT	5.98	0.54	0	1.18 (1.06,1.31)	3.14	0.00	12
Source of control Population
C vs T	78.91	< 0.01	60	0.92 (0.83,1.02)	1.53	0.13	17
CT vs TT	20.50	0.20	22	0.95 (0.88,1.01)	1.59	0.11	17
CC vs TT	29.47	0.02	46	1.00 (0.86,1.16)	0.04	0.97	17
CT + CC vs TT	26.00	0.05	38	0.96 (0.90,1.03)	1.06	0.29	17
CC vs CT + TT	27.06	0.06	38	1.01 (0.94,1.10)	0.32	0.75	18
Hospital
C vs T	13.71	0.01	65	0.97 (0.68,1.38)	0.17	0.86	3
CT vs TT	3.34	0.19	40	0.98 (0.83,1.15)	0.30	0.77	3
CC vs TT	17.29	< 0.01	68	0.83 (0.64,2.03)	0.40	0.69	3
CT + CC vs TT	7.75	0.02	64	0.99 (0.69,1.43)	0.05	0.96	3
CC vs CT + TT	15.24	< 0.01	67	0.82 (0.57,1.80)	0.49	0.62	3
Sample size
≥ 300
C vs T	76.76	< 0.01	66	0.99 (0.87,1.12)	0.19	0.85	12
CT vs TT	12.83	0.30	14	0.99 (0.92,1.06)	0.34	0.74	12
CC vs TT	35.37	< 0.01	59	1.04 (0.86,1.26)	0.42	0.68	12
CT + CC vs TT	21.90	0.03	50	1.00 (0.91,1.10)	0.04	0.97	12
CC vs CT + TT	30.33	< 0.01	64	1.03 (0.90,1.19)	0.47	0.64	13
< 300
C vs T	7.50	0.38	7	0.92 (0.94,1.11)	1.88	0.06	8
CT vs TT	4.34	0.74	0	0.89 (0.78,1.02)	1.74	0.08	8
CC vs TT	12.99	0.07	46	0.82 (0.65,1.04)	1.66	0.10	8
CT + CC vs TT	5.03	0.66	0	0.90 (0.80,1.03)	1.70	0.09	8
CC vs CT + TT	13.13	0.07	47	0.93 (0.75,1.14)	0.73	0.47	8