Table 1. Patient characteristics according to day-28 outcome.
| All patients (n=418) | Survivors (n=215) | Non-survivors (n=203) | Univariate analysis p Value | Multivariate analysis p Value | |
|---|---|---|---|---|---|
| Agea | 55 ± 15 | 53 ± 16 | 57 ± 15 | 0.01 | 0.22 |
| Sex (male)b | 244 (58) | 128 (60) | 116 (57) | 0.62 | |
| Charlson scorea | 4.1 ± 2.1 | 3.9 ± 2.1 | 4.4 ± 2.1 | 0.03 | 0.37 |
| PSa | 1.8 ± 1.0 | 1.7 ± 1.0 | 2.1 ±1.0 | <0.001 | <0.01 |
| Hematological malignanciesb | |||||
| Type | 0.35 | ||||
| Acute leukemia | 239 (57) | 124 (58) | 115 (57) | ||
| Myeloma | 69 (17) | 34 (16) | 35 (17) | ||
| Lymphoma | 53 (13) | 32 (15) | 21 (10) | ||
| Chronic leukemia | 27 (6) | 14 (7) | 13 (6) | ||
| Others | 30 (7) | 11 (5) | 19 (9) | ||
| Disease status | 0.06 | 0.84 | |||
| Newly diagnosed | 129 (31) | 63 (29) | 66 (33) | ||
| Controlled/Remission | 136 (33) | 81 (38) | 55 (27) | ||
| Recurrence/Progression | 156 (37) | 71 (33) | 82 (40) | ||
| Treatment/Condition | |||||
| Autologous HSCT | 43 (10) | 26 (12) | 17 (8) | 0.21 | |
| Allogeneic HSCT | 116 (28) | 56 (26) | 60 (30) | 0.42 | |
| Neutropenia | 124 (30) | 57 (27) | 67 (33) | 0.15 | |
| Reasons for admissionb | 0.02 | NA | |||
| Respiratory | 199 (48) | 92 (43) | 107 (53) | ||
| Hemodynamic | 112 (27) | 69 (32) | 43 (21) | ||
| Metabolic | 63 (15) | 36 (17) | 27 (13) | ||
| Neurologic | 29 (7) | 11 (5) | 18 (9) | ||
| Cardiac arrest | 6 (1) | 1 (0) | 5 (2) | ||
| Others | 9 (2) | 6 (3) | 3 (1) | ||
| Organ failuresb | <0.0001 | NA | |||
| n = 0-1 | 205 (49) | 147 (68) | 58 (29) | ||
| n = 2-3 | 192 (46) | 66 (31) | 124 (61) | ||
| n ≥ 4 | 21 (5) | 2 (1) | 19 (9) | ||
| SOFA scorea | 8 ± 4 | 7 ± 3 | 10 ± 3 | <0.0001 | NA |
| Organ supportsbc | |||||
| IMV | 196 (47) | 51 (24) | 145 (71) | <0.0001 | <0.0001 |
| RRT | 99 (24) | 26 (12) | 73 (36) | <0.0001 | <0.001 |
| Vasopressors | 214 (51) | 89 (41) | 125 (62) | <0.0001 | 0.82 |
| SAPS IIa | 58 ± 24 | 46 ± 16 | 70 ± 26 | <0.001 | NA |
| Length of stay in ICUa | 10 ± 15 | 12 ± 19 | 7 ± 6 | <0.001 | NA |
a
Data expressed as mean ± SD.
b
Data expressed as number (percentage).
c
Within the first 48 hours
HSCT: hematopoietic stem cell transplantation; ICU: intensive care unit; IMV: invasive mechanical ventilation; NA: not applicable; NS: not significant; PS: performance status; RRT: renal replacement therapy; SAPS II: simplified acute physiology score II; SOFA: sequential organ failure assessment.