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. 2016 Mar 8;7(16):22448–22459. doi: 10.18632/oncotarget.7988

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Copyright: © 2016 Chung et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Detection of ELF2, p21 and p27 expression in ELF2-depleted (shELF2#1, shELF2#2) and control (shLuc) SK-Hep1 cells using A. q-RT-PCR and B. western blot, respectively. C. Cell proliferation analysis in ELF2-depleted (shELF2#1, shELF2#2) and control (shLuc) SK-Hep1 cells (upper panel). Cell cycle stages of ELF2-depleted (shELF) and control (shLuc) SK-Hep1 cells detected via flow cytometry (lower panel). D. Schematic diagram showing that T₃/TR negatively regulates ELF2 to suppress cell proliferation via p21/p27 activation. Differences were analyzed using one-way ANOVA, *P < 0.05.