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. 2016 Mar 8;7(16):22474–22485. doi: 10.18632/oncotarget.7965

Figure 3. rhMG53 protects against I/R injury to rat brains.

Figure 3

a. Representative images of TTC staining of rat brain slides showed intravenous delivery of rhMG53 reduced infarct area as compared to saline treatment as controls. IR - rats receiving no treatment of rhMG53; Pre - rhMG53 administered prior to ischemia; Post-0, rhMG53 administered immediately after ischemia; Post-1, rhG53 administered 1 hour post reperfusion; and Post-6, rhMG53 administered 6 hours post reperfusion. b. Infarct sizes of different groups were quantified and summarized. rhMG53 treatment significantly reduced infarct area at different time points of administrations (pre, 0, 1h, 2h and 4h post reperfusion). The beneficial effect of rhMG53 was diminished when the animals were treated by rhMG53 6 h post reperfusion. *P<0.05 vs. I/R (n=7). c. Treatment of rhMG53 also led to significant improvement of behavior of the rats as demonstrated by Zea-Longa score. *P<0.05 vs. I/R (n=7 per group).