Table 2. Samples with co-occurrence of mutations.
| Sample | Type of Cancer | Most frequently mutated genes | Least frequently mutated genes | ||||||
|---|---|---|---|---|---|---|---|---|---|
| KRAS | PIK3CA | KIT | RET | Gene | Mutation | Gene | Mutation | ||
| INV063 | Breast, liver mets | G12D | ABL1 | Y253H | |||||
| INV110 | Rectal | G13D | AKT1 | E17K | |||||
| INV086 | Colon | G13D | AKT3 | G171R | |||||
| INV034 | Cervix | G12D | GNAS | R201H | |||||
| INV198 | Colon | G12D | GNAS | R201H | |||||
| INV161 | Colon | G12C | KIT | D52N | |||||
| INV005 | Rectal, lung mets | G12D | MET | R970C | |||||
| INV017 | Rectal | A146V | NRAS | G12S | |||||
| INV186 | Colon | G13D | NRAS | G13D | |||||
| INV016 | Colon | G12D | E542K | D52N | C634W | ||||
| INV163 | Colon | G13D | E542K & H1047R | D52N | |||||
| INV042 | Breast | Q61R | C420R | CDK4 | R24C | EGFR | P772_H773InsV | ||
| INV028 | Colon | G12D | E542K | ||||||
| INV059 | Colon | G12S | E542K | ||||||
| INV084 | Colon | G13D | Q546R | ||||||
| INV181 | Colon | G12V | Y1021C | ||||||
| INV185 | Colon | G12C | G1049R | ||||||
| INV001 | Colon | G12D | C634Y | ||||||
| INV045 | Colon | C420R | BRAF | V600E | |||||
| INV054 | Colon | G1049R | EGFR | D770_N771>AGG | |||||
| INV177 | Breast | E545K | D52N | ||||||
| INV036 | Cervix | E542K | E839K | ||||||
| INV141 | Colon, liver mets | H1047R | D52N | C634W | |||||
| INV126 | Breast | E542K | E839K | ||||||
| INV088 | Breast, pleural mets | E545K & G1049R | |||||||
| INV134 | Breast, lung mets | L576P | MET | N375S | |||||
| INV055 | Rectal | D52N | PDGFRA | D842V | |||||
| INV081 | Colon | D52N | C634W | ||||||
| INV071 | Breast, pleural mets | D52N | C634W | ||||||
| INV011 | Kidney | MET | R970C | BRAF | L597S | ||||
| INV023 | Ovary | NRAS | G13D | PDGFRA | D1071N | ||||
Most and least frequently mutated genes in samples with co-occurrence mutations
mets: metastasis
Bold represent the most frequent associations: KRAS + PIK3CA; PIK3CA + KIT and KIT + RET