Table 3. Mutation distribution across colorectal cancer samples.
| Sample | Location | Type | Gene | Mutation | %M | Gene | Mutation | %M | Gene | Mutation | %M | Gene | Mutation | %M |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| INV001 | Left colon | Primary | KRAS | G12D | 42.7 | RET | C634Y | 10.5 | ||||||
| INV004 | Left colon | Primary | KRAS | A146V | 23.3 | |||||||||
| INV014 | Left colon | Primary | KRAS | G12D | 35.3 | |||||||||
| INV086 | Left colon | Primary | KRAS | G13D | 39.8 | AKT3 | G171R | 15.1 | ||||||
| INV104 | Left colon | Primary | KRAS | G12V | 31.6 | |||||||||
| INV164 | Left colon | Primary | KRAS | G12D | 33.7 | |||||||||
| INV060 | Left colon | Metastasis | KRAS | Q61R | 36.9 | |||||||||
| INV008 | Left colon | Primary | PIK3CA | G1049R | 14.5 | |||||||||
| INV054 | Left colon | Primary | PIK3CA | G1049R | 10.6 | EGFR | D770_N771>AGG | 11.1 | ||||||
| INV138 | Left colon | Metastasis | PIK3CA | G1049R | 10.7 | |||||||||
| INV081 | Left colon | Primary | KIT | D52N | 27.6 | RET | C634W | 31.8 | ||||||
| INV161 | Left colon | Primary | KIT | D52N | 14.6 | KRAS | G12C | 24.1 | ||||||
| INV141 | Left colon | Metastasis | KIT | D52N | 47.2 | PIK3CA | H1047R | 23.0 | RET | C634W | 42.4 | |||
| INV154 | Left colon | Metastasis | MET | N375S | 34.2 | |||||||||
| INV180 | Left colon | Primary | AKT1 | E17K | 36.6 | |||||||||
| INV186 | Left colon | Primary | KRAS | G13D | 15.2 | NRAS | G13D | 21.4 | ||||||
| INV196 | Left colon | Primary | KRAS | G12V | 14.3 | |||||||||
| INV201 | Left colon | Primary | NRAS | G12D | 24.1 | |||||||||
| INV016 | Right colon | Primary | KRAS | G12D | 10.0 | KIT | D52N | 10.4 | PIK3CA | E542K | 13.4 | RET | C634W | 23.5 |
| INV026 | Right colon | Primary | KRAS | G12D | 35.0 | |||||||||
| INV028 | Right colon | Primary | KRAS | G12D | 14.0 | PIK3CA | E542K | 14.4 | ||||||
| INV031 | Right colon | Primary | KRAS | G12D | 38.6 | |||||||||
| INV059 | Right colon | Primary | KRAS | G12S | 23.4 | PIK3CA | E542K | 19.4 | ||||||
| INV066 | Right colon | Primary | KRAS | G13D | 40.9 | |||||||||
| INV084 | Right colon | Primary | KRAS | G13D | 24.6 | PIK3CA | Q546R | 12.7 | ||||||
| INV163 | Right colon | Primary | KRAS | G13D | 27.0 | KIT | D52N | 20.0 | PIK3CA | E542K | 14.6 | PIK3CA | H1047R | 23.1 |
| INV082 | Right colon | Metastasis | KRAS | A59T | 19.5 | |||||||||
| INV045 | Right colon | Primary | BRAF | V600E | 15.7 | PIK3CA | C420R | 23.3 | ||||||
| INV181 | Right colon | Primary | KRAS | G12V | 31.1 | PIK3CA | Y1021C | 72.0 | ||||||
| INV185 | Right colon | Primary | KRAS | G12C | 15.0 | PIK3CA | G1049R | 15.0 | ||||||
| INV193 | Right colon | Primary | KRAS | G12S | 26.9 | |||||||||
| INV197 | Right colon | Primary | BRAF | V600E | 11.5 | |||||||||
| INV198 | Right colon | Primary | KRAS | G12D | 67.5 | GNAS | R201H | 31.1 | IDH1 | R132C | 44 | |||
| INV017 | Rectum | Primary | KRAS | A146V | 10.8 | NRAS | G12S | 46.0 | ||||||
| INV110 | Rectum | Primary | KRAS | G13D | 36.5 | AKT1 | E17K | 33.9 | ||||||
| INV005 | Rectum | Metastasis | KRAS | G12D | 49.4 | MET | R970C | 48.9 | ||||||
| INV018 | Rectum | Primary | NRAS | Q61R | 23.8 | |||||||||
| INV020 | Rectum | Primary | KIT | D52N | 19.8 | |||||||||
| INV055 | Rectum | Primary | KIT | D52N | 27.8 | PDGFRA | D842V | 20.5 | ||||||
| INV030 | Rectum | Metastasis | KIT | D52N | 16.4 | |||||||||
| INV147 | Rectum | Primary | EGFR | G719S | 22.7 | |||||||||
| INV079 | Unknown | Primary | KRAS | G12D | 58.3 | |||||||||
| INV145 | Unknown | Primary | KRAS | A146T | 16.7 | |||||||||
| INV184 | Unknown | Primary | MET | N375S | 27.5 | |||||||||
| INV190 | Unknown | Metastasis | KRAS | G12C | 33.4 | |||||||||
| INV191 | Unknown | - | KRAS | G12V | 15.4 |
%M represent the percentage of mutant alleles in each reported gene