Table 4. Mutation distribution across breast cancer samples.

Sample	Molecular subtype	Histology	Type	Gene	Mut	%M	Gene	Mut	%M	Gene	Mut	%M	Gene	Mut	%M
INV174	Luminal A	Ductal	Primary	KIT	D52N	15.3
INV096	Luminal A	Ductal	Metastasis	KIT	D52N	23.8
INV095	Luminal A	Ductal	Metastasis	KIT	K550_K558del	17.6
INV107	Luminal A	Lobular	Metastasis	PIK3CA	N345K	12.5
INV033	Luminal A	Ductal	Metastasis	PIK3CA	E542K	32.0
INV117	Luminal A	Ductal	Metastasis	PIK3CA	M1043I	15.5
INV072	Luminal A	Lobular	Metastasis	PIK3CA	H1047R	15.8
INV205	Luminal A	Ductal	Metastasis	PIK3CA	H1047R	37.7
INV169	Luminal B	Ductal	Primary	AKT1	E17K	20.4
INV170	Luminal B	Ductal	Metastasis	AKT1	E17K	59.9
INV128	Luminal B	Ductal	Metastasis	EGFR	H773_V774insH	30.9
INV071	Luminal B	Lobular	Metastasis	KIT	D52N	14.3	RET	C634W	48.3
INV073	Luminal B	Ductal	Metastasis	KIT	Y553_Q556del	11.3
INV155	Luminal B	Not specified	Primary	MET	N375S	35.1
INV173	Luminal B	Ductal	Metastasis	PIK3CA	E542K	37.8
INV126	Luminal B	Lobular	Primary	PIK3CA	E542K	12.0	KIT	E839K	14.4
INV105	Luminal B	Ductal	Metastasis	PIK3CA	E545K	57.4
INV177	Luminal B	Ductal	Primary	PIK3CA	E545K	59.3	KIT	D52N	10.0
INV077	Luminal B	Ductal	Metastasis	PIK3CA	E545K	30.4
INV088	Luminal B	Ductal	Metastasis	PIK3CA	E545K	66.3	PIK3CA	G1049R	19.2
INV101	Luminal B	Ductal	Primary	PIK3CA	H1047R	20.5
INV092	Luminal B	Ductal	Primary	RET	C634W	31.3
INV042	Basal like	Ductal	Primary	PIK3CA	C420R	12.1	CDK4	R24C	13.2	EGFR	P772_H773insV	13.2	KRAS	Q61R	12.4
INV057	Basal like	Ductal	Primary	PIK3CA	H1047R	18.9
INV044	Basal like	Lobular	Metastasis	PIK3CA	H1047R	19.5
INV069	Her2	Ductal	Metastasis	PIK3CA	M1043I	49.6
INV074	Her2	Tubule-lobular	Metastasis	PDGFRA	D842V	32.2
INV094	Her2	Ductal	Primary	KRAS	G12D	14.8
INV134	Her2	Ductal	Metastasis	KIT	L576P	13.3	MET	N375S	17.6
INV070	Her2	Ductal	Metastasis	CDK4	R24H	10.4
INV063	Her2	Ductal	Metastasis	ABL1	Y253H	12.2	KRAS	G12D	22.6

Mut, mutation; %M represent the percentage of mutant alleles in each reported gene