Figure 5. Rag1^−/− mice succumb to infection by EcN, while tolerable to Symbioflor-2.

Rag1^−/− mice were infected i.v. with 5×10⁶ Symbioflor-2 or EcN upon which the host phenotype was evaluated. A. Host body weight comparison between Wild-type (WT) and Rag1^−/− mice over the course of systemic infection with Symbioflor-2. B. Tolerability to high dose (100-fold) Symbioflor-2 infection in Rag1^−/− mice. C. WT and Rag1^−/− host body weight profile upon systemic inoculation with EcN. Rag1^−/− mice were analogously treated with PBS as control (denoted “CTRL”). D. Survival rate of WT and Rag1^−/− mice with probiotic infection. N=5-8. Mean ± SEM.