Table 3. Logistic regression analysis of rs3846662 polymorphism in AD patients and controls.
| Model | Total samplea | P for ApoE × SNP interaction | ApoE ε4 allele (–)b | ApoE ε4 allele (+)b | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
| Dominant | 0.796 (0.657–0.965) | 0.020* | 0.109 | 0.735 (0.593–0.912) | 0.005* | 1.080 (0.709–1.644) | 0.721 |
| Recessive | 1.155 (0.949–1.406) | 0.151 | 0.163 | 1.073 (0.859–1.340) | 0.536 | 1.527 (0.988–2.361) | 0.057 |
| Additive | 0.966 (0.856–1.089) | 0.569 | 0.063 | 0.908 (0.793–1.041) | 0.168 | 1.200 (0.926–1.553) | 0.168 |
Abbreviations: P, P-value calculated from binary logistic regression; SNP: single nucleotide polymorphism; Dominant: dominant model; Recessive: recessive model; Additive: additive model.
a
Adjusted for age, gender and ApoE ε4 status.
b
Adjusted for age and gender.
*
P < 0.05, significant values.