Table 3. Stratification Analysis Of Risk Genotypes With Neuroblastoma Susceptibility.
Variables | rs110419(cases/controls) | OR | P | Adjusted OR a | Pa | Combined | OR | P | Adjusted ORa | Pa | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AG/GG | (95% CI) | (95% CI) | 0–3 | 4 | (95% CI) | (95% CI) | |||||
Age, month | ||||||||||||
≤ 18 | 37/74 | 64/159 | 0.81 (0.49–1.31) | 0.386 | 0.80 (0.49–1.31) | 0.378 | 88/187 | 13/46 | 0.60 (0.31–1.17) | 0.134 | 0.59 (0.30–1.16) | 0.124 |
> 18 | 66/85 | 89/213 | 0.54 (0.36–0.81) | 0.003 | 0.54 (0.36–0.80) | 0.003 | 142/248 | 13/50 | 0.45 (0.24–0.87) | 0.016 | 0.45 (0.24–0.86) | 0.015 |
Gender | ||||||||||||
Females | 43/73 | 60/160 | 0.64 (0.39–1.03) | 0.065 | 0.64 (0.40–1.03) | 0.068 | 92/199 | 11/34 | 0.70 (0.34–1.44) | 0.334 | 0.71 (0.34–1.46) | 0.346 |
Males | 60/86 | 93/212 | 0.63 (0.42–0.95) | 0.027 | 0.63 (0.42–0.95) | 0.026 | 138/236 | 15/62 | 0.41 (0.23–0.76) | 0.004 | 0.42 (0.23–0.76) | 0.004 |
Sites of origin | ||||||||||||
Adrenal gland | 25/159 | 21/372 | 0.36 (0.20–0.66) | 0.001 | 0.36 (0.19–0.66) | 0.001 | 42/435 | 4/96 | 0.43 (0.15–1.23) | 0.117 | 0.43 (0.15–1.24) | 0.117 |
Retroperitoneal | 26/159 | 61/372 | 1.00 (0.61–1.65) | 0.991 | 1.00 (0.61–1.65) | 0.993 | 76/435 | 11/96 | 0.66 (0.34–1.28) | 0.217 | 0.65 (0.33–1.27) | 0.203 |
Mediastinum | 38/159 | 52/372 | 0.59 (0.37–0.92) | 0.022 | 0.59 (0.37–0.93) | 0.024 | 85/435 | 5/96 | 0.27 (0.11–0.68) | 0.005 | 0.27 (0.11–0.68) | 0.006 |
Others | 12/159 | 13/372 | 0.46 (0.21–1.04) | 0.061 | 0.46 (0.20–1.03) | 0.058 | 23/435 | 2/96 | 0.39 (0.09–1.70) | 0.212 | 0.37 (0.09–1.61) | 0.185 |
Clinical stage | ||||||||||||
I + II + 4s | 46/159 | 80/372 | 0.74 (0.50–1.12) | 0.154 | 0.74 (0.49–1.11) | 0.140 | 115/435 | 11/96 | 0.43 (0.23–0.84) | 0.013 | 0.42 (0.22–0.82) | 0.010 |
III + IV | 52/159 | 69/372 | 0.57 (0.38–0.85) | 0.006 | 0.56 (0.37–0.84) | 0.005 | 107/435 | 14/96 | 0.59 (0.33–1.08) | 0.087 | 0.61 (0.33–1.12) | 0.108 |
Adjusted for age and gender.