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. 2016 Mar 18;7(16):22770–22778. doi: 10.18632/oncotarget.8178

Table 3. Stratification Analysis Of Risk Genotypes With Neuroblastoma Susceptibility.

Variables rs110419(cases/controls) OR P Adjusted OR a Pa Combined OR P Adjusted ORa Pa
AA AG/GG (95% CI) (95% CI) 0–3 4 (95% CI) (95% CI)
Age, month
 ≤ 18 37/74 64/159 0.81 (0.49–1.31) 0.386 0.80 (0.49–1.31) 0.378 88/187 13/46 0.60 (0.31–1.17) 0.134 0.59 (0.30–1.16) 0.124
 > 18 66/85 89/213 0.54 (0.36–0.81) 0.003 0.54 (0.36–0.80) 0.003 142/248 13/50 0.45 (0.24–0.87) 0.016 0.45 (0.24–0.86) 0.015
Gender
 Females 43/73 60/160 0.64 (0.39–1.03) 0.065 0.64 (0.40–1.03) 0.068 92/199 11/34 0.70 (0.34–1.44) 0.334 0.71 (0.34–1.46) 0.346
 Males 60/86 93/212 0.63 (0.42–0.95) 0.027 0.63 (0.42–0.95) 0.026 138/236 15/62 0.41 (0.23–0.76) 0.004 0.42 (0.23–0.76) 0.004
Sites of origin
 Adrenal gland 25/159 21/372 0.36 (0.20–0.66) 0.001 0.36 (0.19–0.66) 0.001 42/435 4/96 0.43 (0.15–1.23) 0.117 0.43 (0.15–1.24) 0.117
 Retroperitoneal 26/159 61/372 1.00 (0.61–1.65) 0.991 1.00 (0.61–1.65) 0.993 76/435 11/96 0.66 (0.34–1.28) 0.217 0.65 (0.33–1.27) 0.203
 Mediastinum 38/159 52/372 0.59 (0.37–0.92) 0.022 0.59 (0.37–0.93) 0.024 85/435 5/96 0.27 (0.11–0.68) 0.005 0.27 (0.11–0.68) 0.006
 Others 12/159 13/372 0.46 (0.21–1.04) 0.061 0.46 (0.20–1.03) 0.058 23/435 2/96 0.39 (0.09–1.70) 0.212 0.37 (0.09–1.61) 0.185
Clinical stage
 I + II + 4s 46/159 80/372 0.74 (0.50–1.12) 0.154 0.74 (0.49–1.11) 0.140 115/435 11/96 0.43 (0.23–0.84) 0.013 0.42 (0.22–0.82) 0.010
 III + IV 52/159 69/372 0.57 (0.38–0.85) 0.006 0.56 (0.37–0.84) 0.005 107/435 14/96 0.59 (0.33–1.08) 0.087 0.61 (0.33–1.12) 0.108
a

Adjusted for age and gender.