Table 4. False-positive report probability values for the associations between neuroblastoma susceptibility and the frequency of genotypes of the LMO1 gene.
Genotype | Crude OR (95% CI) | Pa | Statistical powerb | Prior probability | ||||
---|---|---|---|---|---|---|---|---|
0.25 | 0.1 | 0.01 | 0.001 | 0.0001 | ||||
LMO1 rs110419 A > G | ||||||||
AG vs. AA | 0.66 (0.47–0.91) | 0.012 | 0.544 | 0.064 | 0.169 | 0.691 | 0.958 | 0.996 |
GG vs. AA | 0.57 (0.36–0.90) | 0.017 | 0.284 | 0.149 | 0.344 | 0.852 | 0.983 | 0.998 |
AG/GG vs. AA | 0.64 (0.47–0.87) | 0.004 | 0.368 | 0.033 | 0.093 | 0.531 | 0.919 | 0.991 |
AG/GG vs. AA | ||||||||
> 18 | 0.54 (0.36–0.81) | 0.003 | 0.140 | 0.053 | 0.143 | 0.647 | 0.949 | 0.995 |
Males | 0.63 (0.42–0.95) | 0.027 | 0.382 | 0.173 | 0.386 | 0.873 | 0.986 | 0.999 |
Adrenal gland | 0.36 (0.20–0.66) | 0.001 | 0.027 | 0.098 | 0.247 | 0.783 | 0.973 | 0.997 |
Mediastinum | 0.59 (0.37–0.92) | 0.022 | 0.285 | 0.185 | 0.406 | 0.882 | 0.987 | 0.999 |
Stage III + IV | 0.57 (0.38–0.85) | 0.006 | 0.215 | 0.079 | 0.204 | 0.738 | 0.966 | 0.996 |
Protective genotypes | ||||||||
4 vs. 0–3 | 0.51 (0.32–0.81) | 0.005 | 0.148 | 0.084 | 0.215 | 0.751 | 0.968 | 0.997 |
> 18 | 0.45 (0.24–0.87) | 0.016 | 0.141 | 0.258 | 0.510 | 0.92 | 0.991 | 0.999 |
Males | 0.41 (0.23–0.76) | 0.004 | 0.076 | 0.139 | 0.326 | 0.842 | 0.982 | 0.998 |
Mediastinum | 0.27 (0.11–0.68) | 0.005 | 0.040 | 0.284 | 0.543 | 0.929 | 0.992 | 0.999 |
Stage I + II + 4s | 0.43 (0.23–0.84) | 0.013 | 0.115 | 0.248 | 0.497 | 0.916 | 0.991 | 0.999 |
Chi-square test was used to calculate the genotype frequency distributions
Statistical power was calculated using the number of observations in the subgroup and the OR and P values in this table.