Table 4. Univariate and multivariate survival analysis of the patients with lung adenocarcinoma (n = 335).

	Mean Survival (months)	Univariate analysis			Multivariate Analysis
		HR	95% CI	p value	HR	95% CI	p value
Age < 65 vs ≥ 65	59.0 vs 58.0	0.87	0.55~1.36	0.538	1.20	0.76~1.88	0.429
Gender female vs male	63.0 vs 55.0	1.71	1.12~2.61	0.013	2.04	1.24~3.35	0.005
Smoking No vs Yes	59.5 vs 56.2	0.98	0.62~1.57	0.947	0.69	0.40~1.17	0.384
Stage				< 0.0001			< 0.0001
I	69.1				(Reference)
II	54.8				3.03	1.41~6.51
III	56.5				3.95	1.96~7.98
IV	31.4				8.76	3.86~19.9
Total mutation ≤ 4 vs > 4	61.0 vs 48.4	2.19	1.13~4.24	0.020	1.81	1.05~3.13	0.034