Table 3. Association between clinical characteristics and OS and DFS by univariate analysis.
| OS | DFS | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| MALL expression | ||||
| Positive vs. negative | 0.54 (0.34, 0.86) | 0.009* | 0.56 (0.35, 0.88) | 0.013* |
| Age (y) | ||||
| ≥65 vs. <65 | 0.96 (0.61, 1.53) | 0.875 | 0.98 (0.62, 1.55) | 0.938 |
| Gender | ||||
| Male vs. female | 0.75 (0.46, 1.20) | 0.223 | 0.88 (0.56, 1.38) | 0.581 |
| Tumor location | ||||
| Transverse vs. right | 0.80 (0.32, 1.93) | 0.618 | 0.83 (0.34, 1.98) | 0.669 |
| Left vs. right | 0.96 (0.42, 2.19) | 0.920 | 0.91 (0.40, 2.08) | 0.826 |
| Sigmoid vs. right | 1.06 (0.64, 1.76) | 0.808 | 1.18 (0.72, 1.92) | 0.516 |
| T category | ||||
| T2 vs. T1 | 0.30 (0.43, 2.15) | 0.232 | 0.48 (0.81, 2.89) | 0.425 |
| T3 vs. T1 | 0.95 (0.22, 4.09) | 0.944 | 1.26 (0.30, 5.34) | 0.756 |
| T4 vs. T1 | 2.81 (0.68, 11.55) | 0.152 | 2.96 (0.72, 12.18) | 0.132 |
| N category | ||||
| N1 vs. N0 | 4.02 (2.18, 7.43) | <0.001* | 2.73 (1.57, 4.73) | <0.001* |
| N2 vs. N0 | 14.07 (7.54, 26.27) | <0.001* | 10.22 (5.78, 18.09) | <0.001* |
| M category | ||||
| M1 vs. M0 | 14.74 (8.15, 26.67) | <0.001* | 9.93 (4.91, 20.07) | <0.001* |
| Vessin invasion | ||||
| Yes vs. no | 4.68 (2.55, 8.60) | <0.001* | 4.12 (2.16, 7.86) | <0.001* |
| Differentiation | ||||
| Moderate vs. well | 2.37 (1.34, 4.18) | 0.003* | 2.26 (1.35, 3.79) | 0.002* |
| Poor vs. well | 7.50 (4.11, 13.68) | <0.001* | 4.87 (2.64, 8.97) | <0.001* |
| AJCC stage | ||||
| III-IV vs. I-II | 6.66 (3.76, 11.82) | <0.001* | 4.24 (2.59, 6.92) | <0.001* |
Abbreviations: OS, overall survival; DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; AJCC, American Joint Committee on Cancer
*
P<0.05 indicates a significant difference.