Table 3. Adverse events by frequency and grade in entire study population (N = 48).
| Adverse Event | Grade | Total (N) | % | ||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |||
| Fatigue | 12 | 13 | 2 | 27 | 56.3 | ||
| Anemia | 9 | 6 | 3 | 18 | 37.5 | ||
| Anorexia | 16 | 2 | 18 | 37.5 | |||
| Dyspnea | 9 | 5 | 1 | 1 | 1 | 17 | 35.4 |
| Cough | 14 | 2 | 16 | 33.3 | |||
| Nausea | 14 | 14 | 29.2 | ||||
| Hyponatremia | 12 | 12 | 25 | ||||
| Hyperglycemia | 8 | 2 | 1 | 11 | 22.9 | ||
| Headache | 8 | 2 | 10 | 20.8 | |||
| Lymphopenia | 6 | 1 | 3 | 10 | 20.8 | ||
| Pain abdomen | 8 | 1 | 1 | 10 | 20.8 | ||
| Pain back | 8 | 2 | 10 | 20.8 | |||
| Sensory neuropathy | 8 | 2 | 10 | 20.8 | |||
| Diarrhea | 8 | 1 | 9 | 18.8 | |||
| Constipation | 4 | 3 | 7 | 14.6 | |||
| Elevated alkaline phosphatase | 4 | 1 | 2 | 7 | 14.6 | ||
| Rash | 5 | 2 | 7 | 14.6 | |||
| Dehydration | 3 | 2 | 1 | 6 | 12.5 | ||
| Elevated creatinine | 6 | 6 | 12.5 | ||||
| Thrombocytopenia | 6 | 6 | 12.5 | ||||
| Vomiting | 6 | 6 | 12.5 | ||||
| Edema peripheral | 3 | 1 | 1 | 5 | 10.4 | ||
| Neutropenia | 5 | 5 | 10.4 | ||||
| Pain shoulder | 3 | 2 | 5 | 10.4 | |||
| Fever | 3 | 1 | 4 | 8.3 | |||
| Hyperkalemia | 4 | 4 | 8.3 | ||||
| Light sensitivity | 4 | 4 | 8.3 | ||||
| Pain leg | 2 | 2 | 4 | 8.3 | |||
| Proteinuria | 3 | 1 | 4 | 8.3 | |||
| Dyspnea on exertion | 3 | 1 | 4 | 8.3 | |||
| Dizziness | 1 | 1 | 1 | 3 | 6.3 | ||
| Elevated bun | 3 | 3 | 6.3 | ||||
| Hypocalcemia | 1 | 2 | 3 | 6.3 | |||
| Hypokalemia | 2 | 1 | 3 | 6.3 | |||
| Elevated prothrombin time | 2 | 1 | 3 | 6.3 | |||
| Insomnia | 3 | 3 | 6.3 | ||||
| Leukocytosis | 3 | 3 | 6.3 | ||||
| Pain hip | 1 | 2 | 3 | 6.3 | |||
| Pain knee | 3 | 3 | 6.3 | ||||
| Tingling extremities | 3 | 3 | 6.3 | ||||
| Urine color change | 1 | 2 | 3 | 6.3 | |||
| Vision blurred | 3 | 3 | 6.3 | ||||
| Weakness | 2 | 1 | 3 | 6.3 | |||
| Weight loss | 3 | 3 | 6.3 | ||||
| Urinary tract infection | 2 | 1 | 3 | 6.3 | |||
| Hypophysitis | 3 | 3 | 6.3 | ||||